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[DOI] [PMC free article] [PubMed] [Google Scholar] 201.Constantinescu-Bercu A., Kessler A., de Groot R., Dragunaite B., Heightman M., Hillman T., Price L.C., Brennan E., Sivera R., Vanhoorelbeke K., et al

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Alcohol also decreases the production and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), both of which are vital for testosterone production

However, arginine level depletion in patients sustained for about a week and returned to baseline level, suggesting that resistance on ADI-PEG20 may arise upon prolonged drug treatment [140, 141]